Magnetic resonance spectroscopy reveals oral lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate
Rafal Janik1, Lynsie A.M. Thomason2, and Greg J. Stanisz1,2,3
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Nerurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland
We previously have demonstrated that
administration of Lactobacillus rhamnosus
(JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and
-B receptor subtypes in specific brain regions, accompanied by reductions in
anxiety and depression-related behaviours. In the present study, using magnetic resonance
spectroscopy (MRS), we quantitatively assessed two clinically validated
biomarkers of brain activity and function, glutamate + glutamine (Glx) and
total N-acetyl aspartate + N-acetylaspartylglutamic acid (tNAA), as well as
GABA, the chief brain inhibitory neurotransmitter.
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