Abstract #4088

Quantitative pH using chemical exchange saturation transfer and phosphorous spectroscopy

Zhuozhi Dai^1,2, Phillip Zhe Sun³, Gang Xiao⁴, Gen Yan², Yanlong Jia², Zhiwei Shen⁵, Alan H. Wilman¹, and Renhua Wu^2,5

¹Biomedical engineering, University of Alberta, Edmonton, AB, Canada, ²Medical Imaging, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China, People's Republic of, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH and Harvard Medical School, Charlestown, MA, United States, ⁴Math and Information Technology, Hanshan Normal University, Chaozhou, China, People's Republic of, ⁵Provincial key laboratory of medical molecular imaging, Shantou, China, People's Republic of

pH is a very important biochemical property that changes in many pathological states. Monitoring pH is of significance in early diagnosis and treatment therapy. However, there is lack of non-invasive methods to image pH in vivo effectively. Our study quantified the pH value using a chemical exchange saturation transfer (CEST) method in rat brain and established a strong correlation of pH between CEST and 31P-MRS in vivo, Pearson correlation factor is 0.819, P < 0.01. Because CEST imaging has superior spatial resolution to 31P-MRS, CEST may provide an alternative, straightforward, and effective way to obtain quantitative pH images in vivo.

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