Abstract #4109

Metabolic and morphological characterization of the triple transgene mouse model of Alzheimer disease: effects of palmitoylethanolamide on the onset and progression of the AD-pathology

Rossella Canese¹, Giulia Carpinelli¹, Gianmauro Palombelli¹, Caterina Scuderi², Luca Steardo², and Tommaso Cassano³

¹Cell Biology and Neurosciences, Istituto Superiore di Sanita', Roma, Italy, ²Department of Physiology and Pharmacology “Vittorio Erspamer”., University of Rome SAPIENZA, Rome, Italy, ³Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Foggia, Foggia, Italy

Alzheimer disease (AD) is characterized clinically by progressive cognitive decline, and pathologically by the presence in the brain of senile plaques composed primarily of amyloid-beta peptide and neurofibrillary tangles containing hyperphosphorylated tau protein. Here we investigated the effects ofa naturally occurring amide of ethanolamine and palmitic acid (PEA), abundant in the CNS to contrast the AD phenotype in triple transgene (PS1, APP and Tau) mice model, by in vivo 1H MRI and MRS and histology. Our data indicate that PEA treatment affects brain metabolism as a function of age and that PEA rescues altered molecular pathways that can mimic some traits of AD

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