Abstract #4126

Functional Disconnectivity in Schizophrenia Patients with Auditory Hallucinations: a Dynamic Resting-State Functional MRI Study with a Multiband EPI Sequence

Wenjing Zhang¹, Wei Deng², Siyi Li¹, John Sweeney³, Qiyong Gong¹, and Su Lui¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ³Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, United States

A simultaneous multi-slice multiband EPI sequence, which could significantly increase temporal resolution for the fMRI scanning, was adopted to investigate the dynamic functional connectivity in the schizophrenia patients with auditory hallucinations. We found that, relative to traditional static functional connectivity calculation, dynamic analysis evaluated with multiband EPI provides much more information, including more widespread aberrant functional connectivity maps across different states and their temporal variability over time. The expanded information may help to give better insight into the pathological processes and subsequently reveal the spontaneous model of affected networks in schizophrenia.

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