Ravi Prakash Reddy Nanga1, David R. Roalf2, Petra Rupert2, Megan Quarmley2, Hari Hariharan1, Mark Elliott1, Raquel E. Gur2, Paul J. Moberg2, Ravinder Reddy1, and Bruce I. Turetsky2
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
In this glutamate Chemical Exchange Saturation Transfer (GluCEST) study, typically developing individuals and youth at clinical high
risk for psychosis exhibit subtle, but significant, abnormalities in brain
glutamate, similar to patients with schizophrenia in the entire cortical area. GluCEST
technique holds distinct promise for understanding neurodevelopmental
contributions to schizophrenia pathophysiology.