Abstract #4145

Abnormal brain structure is associated with depression and anxiety in obese patients using DTI

Yi-Chun Liu¹, Vincent Chin-Hung Chen², Hse-Huang Chao³, Ming-Chou Ho⁴, and Jun-Cheng Weng^1,5

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ³Tiawan Center for Metabolic and Bariatric Surgery, Jen-Ai Hospital, Taichung, Taiwan, ⁴Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ⁵Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Since there is more and more delicious food in our daily life, people cannot resist the attraction to food. Therefore, obesity has become an important issue in modern society. Previous studies used food pictures to stimulate obese patients and used functional MRI to find the brain regions with increased activity. However, few studies mentioned about particular brain structure changes in obese patient. Noninvasive diffusion tensor imaging (DTI) are able to observe the water diffusion in the brain on the microscopic level for the early detection of white matter structural changes. Therefore, we used DTI to find the differences of brain structures between obese patients and healthy controls. The correlation between clinical and the DTI indices were also calculated and discussed. The clinical indices included body mass index (BMI), and measures of anxiety and depression.

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