Altered whole brain functional connectivity in drug-naive patients with obsessive–compulsive disorder: A resting-state functional magnetic resonance imaging study
Xinyu Hu1, Xi Yang2, Yanchun Yang2, Qiyong Gong1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China, People's Republic of
We analysis whole brain connectivity in a relatively large sample of drug-naive patients
with obsessive-compulsive disorder (OCD) using a novel graph-theory approach
known as functional connectivity strength (FCS) to identify brain regions displaying high-degree centrality of
connectivity. Based on the new
approach of FCS, our findings demonstrated obvious significant hyperactivity of
default mode network (DMN) in OCD patients at resting state. Furthermore, our results provided
evidence that besides the prevailing model of cortical–striatal–thalamic–cortical circuits in OCD, the disequilibrium between the DMN and the salience network (SN) might be associated with the pathophysiology of OCD.
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