Abstract #4185

Correlated MR imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

Michael Breckwoldt¹, Julia Bode², Felix Kurz¹, Angelika Hoffmann¹, Martin Ott², Katrin Deumelandt², Gergely Solecki², Sara Chiblak², Amir Abdollahi², Frank Winkler², Michael Platten², Sabine Heiland¹, Martin Bendszus¹, and Björn Tews²

¹Neuroradiology, University of Heidelberg, Heidelberg, Germany, ²German Cancer Research Center, Heidelberg, Germany

Gliomas are malignant brain tumors that depend on neoangiogenesis. Novel imaging methods are required to assess vascularization status, treatment effects and disease progression. We developed a combined MR and optical vascularization “tool kit” to study neoangiogenesis in mouse glioma models. We use T2* post contrast imaging (iron oxide nanoparticle or Gd-based) of vascular susceptibility signals and innovative ultramicroscopy (UM) of cleared brains. T2* imaging identifies single arterioles and venules in glioma development. Correlated UM of fluorescently labeled microvessels shows typical features of pathological vessels (increased caliber, density and tortuousness). Thus, MR-UM facilitates the preclinical search for more effective antiangiogenic agents.

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