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Abstract #4189

Characteristics of apparent relative oxygen extraction fraction (rOEF) in human high grade glioma

Christine Preibisch1,2, Mathias Lukas3, Anne Kathrin Kluge1, Claus Zimmer1, Stefan Förster3,4, and Thomas Pyka3

1Dept. of Neuroradiology, Technische Universität München, Munich, Germany, 2Clinic for Neurology, Technische Universität München, Munich, Germany, 3Clinic for Nuclear Medicine, Technische Universität München, Munich, Germany, 4Clinic for Nuclear Medicine, Klinikum Bayreuth, Bayreuth, Germany

Hypoxia plays an important role in prognosis and therapy response of cancer. This study explores the characteristics of multi-parametric measurements of relative oxygen extraction fraction (rOEF) in a sample of 36 mostly high grade glioma patients. This study confirms previous results in human glioma where rOEF values were found to increase with tumor grade but does not find a similar increase of a supposedly hypoxic tumor area with tumor grade. According to present results, high rOEF values, supposedly corresponding to a high oxygen extraction, prevail in edematous tissue with low rCBV. Whether this translates into tissue hypoxia, needs further investigation.

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