Abstract #4193

Comparison of ferumoxytol and gadolinium enhancement changes in response to Avastin in high grade glioma patients

Andrea Horváth^1,2,3, Csanád Várallyay¹, Daniel Schwartz¹, Prakash Ambady¹, Péter Bogner⁴, and Edward Neuwelt¹

¹Department of Neurology, Oregon Health and Science University, Portland, OR, United States, ²Department of Neurosurgery, University of Pécs, Pécs, Hungary, ³Diagnsotic Center of Pécs, Pécs, Hungary, ⁴Department of Radiology, University of Pécs, Pécs, Hungary

Ferumoxytol is an alternative, investigational, iron-based MRI contrast agent, which might be beneficial in the accurate diagnosis of treated glioma patients. In this study we investigated how gadolinium and 24 hour ferumoxytol enhancement change as a result of Avastin treatment. The enhancement volumes and normalized signal intensities before and after Avastin treatment were calculated with histogram analysis and were compared between contrast agents. Changes in enhancement volumes and in signal intensities in response to Avastin were not different between contrast agents. Ferumoxytol shows good potential in brain tumor imaging.

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