Optimized image reconstruction for high resolution cerebral blood volume mapping with Ferumoxytol
R. Marc Lebel1,2,3, Csanad G Varallyay4, and Edward A Neuwelt4
1GE Healthcare, Calgary, AB, Canada, 2Radiology, University of Calgary, Calgary, AB, Canada, 3Biomedical Engineering, University of Calgary, Calgary, AB, Canada, 4Neurology, Oregon Health and Science University, Portland, OR, United States
Quantitative or semi-quantitative mapping of
cerebral blood volume typically involves complex modeling of a dynamic
gadolinium-enhanced acquisition. Off-label use of ferumoxytol is being explored
as a mechanism for high-resolution quantification of cerebral blood volume.
Acquisition involves high-resolution pre- and post-contrast T2*-weighted scans;
quantification is straightforward and does not require fitting. We present a
multi-echo acquisition and optimal quantification algorithm for improved
detection of ferumoxytol-based blood volume measurements. Our approach provides
high dynamic range and minimal noise amplification.
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