Abstract #4335

Brain Connectivity Analysis of Parkinson's Disease and “Scans Without Evidence for Dopaminergic Deficit" Patients

Tiago Constantino^1,2,3, André Santos Ribeiro⁴, Ricardo Maximiano³, John Mcgonigle⁴, David Nutt⁴, and Hugo Alexandre Ferreira³

¹Lisbon School of Health Technology-ESTeSL, Lisbon, Portugal, ²Spitalzentrum Biel, Biel, Switzerland, ³Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisbon, Portugal, ⁴Centre for Neuropsychopharmacology, Imperial College London, London, United Kingdom

In this work we propose a comparison study between “Scans Without Evidence for Dopaminergic Deficit" (SWEDD) and Parkinson’s Disease (PD) patients against healthy subjects using the MIBCA toolbox. Here, we studied the difference in imaging and connectivity metrics obtained from anatomical (T1-weighted) and structural (Diffusion Tensor Imaging) data between the three groups. Results showed increased mean diffusivity in the frontal pole, rostral middle frontal gyrus and superior frontal gyrus between SWEDD and PD patients, which can be related with the dopaminergic mesocortical pathway degeneration in PD. These preliminary results help clarify the differences between SWEDD and PD patients.

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