Evaluation of perfusion and hypoxia parameters in healthy subjects and patients with high-grade carotid artery stenosis
Stephan Kaczmarz1, Jens Göttler1, Anne Kluge1, Dimitrios C. Karampinos2, Claus Zimmer1, and Christine Preibisch1,3
1Department of Neuroradiology, Technische Universität München, Munich, Germany, 2Department of Radiology, Technische Universität München, Munich, Germany, 3Clinic for Neurology, Technische Universität München, Munich, Germany
Severe intracranial arterial stenosis (SIAS)
is a major health issue as it often accounts for strokes. Here, we present
preliminary data from a clinical study in patients with SIAS compared to
healthy controls. The major aim was to evaluate the reliability of perfusion
and oxygenation related measures by analyzing their hemispheric symmetry to assess
their potential diagnostic capabilities. Preliminary results imply
symmetry of all measures between hemispheres of healthy controls. Regarding
patients, only pCASL-based CBF implies a reduced perfusion on the side of
carotid artery stenosis which is in accordance to recent literature and is currently
under further investigation.
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