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Abstract #4392

A comprehensive assessment of cervical cord lesions in patients with multiple sclerosis on T1-MPRAGE at 3T: relationship with cord atrophy and disability

Paola Valsasina1, Maria Assunta Rocca1, Paolo Preziosa1, Mohammad Ahmad Abdullah Ali Aboulwafa1,2, Mark Andrew Horsfield3, Giancarlo Comi4, Andrea Falini5, and Massimo Filippi1

1Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Clinical Neurology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, 3Xinapse System Ltd, West Bergholt, Essex, United Kingdom, 4Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 5Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, we performed a comprehensive assessment of cervical cord lesions in 133 patients with multiple sclerosis (MS) on 3D T1-weighted scans at 3.0 T. Lesion occurrence, regional distribution, influence on cord atrophy and disability were evaluated. T1 lesions were detected in a large proportion (85%) of MS patients, with a higher frequency of cord lesions in the progressive than in the relapsing forms of the disease. There was only a modest correlation between cord T1 lesions and atrophy. Both cord T1 lesions and atrophy were significant and independent contributors to patient disability.

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