Magnetisation Transfer Ratio (MTR) Measurements in the Lumbar cord: A Pilot Study using ZOOM-EPI at 3T
Rebecca Sara Samson1, Marco Battiston1, Claudia Angela Michela Gandini Wheeler-Kingshott1,2, and Marios C Yiannakas1
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, 2Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy
Magnetisation Transfer Ratio (MTR), and quantitative Magnetisation Transfer
(MT) parameters have proven to be sensitive to the diseased spinal cord (SC),
however in vivo quantitative imaging
of the cord is challenging. Rapid acquisition sequences such as Echo Planar
Imaging (EPI) are desirable but may suffer from artefacts and image
distortions. Here we present results from the use of single-shot ZOOM-EPI to
reduce acquisition time and distortions in SC MTR mapping. The mean SC MTR value for 9 subjects was 38.8 (±4.05). The mean scan-rescan coefficient
of variation for measuring SC MTR (from 5 subjects) was 4.39%.
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