Jennifer Lefeuvre1,2, Joseph R Guy1, Nick Luciano1, Emily Leibovitch1, Mathieu D Santin2, Afonso C Silva1, Steve Jacobson1, Stéphane Lehericy2, Daniel S Reich1, and Pascal Sati1
1NINDS, NIH, Bethesda, MD, United States, 2INSERM U1127/CNRS UMR7225, CENIR, Brain and Spine Institute, Paris, France
Multiple
sclerosis (MS) is a demyelinating disease that affects the entire central
nervous system, with more than 90% of patients showing focal or diffuse
abnormalities in the spinal cord (SC). Experimental autoimmune
encephalomyelitis (EAE) in marmosets is an attractive animal model of MS due to
its radiological presentation with brain lesions that mimic MS1. However,
spinal cord lesions in marmoset EAE have not yet been well characterized. The
proposed methodology allows high-quality, high-resolution imaging of SC lesions
in autopsied marmosets with EAE. The artifact-free images allowed accurate
detection of focal and confluent rim lesions along the edges of the SC.
