Abstract #4409

Multisite feasibility study of spinal cord gray matter and total cord areas measurements on 2D Phase Sensitive Inversion Recovery images

Nico Papinutto¹, Esha Datta¹, Alyssa H Zhu¹, Julio Carballido-Gamio², Regina Schlaeger^1,3, Sinyeob Ahn⁴, Kevin Johnson⁴, Lara Stables⁵, William A Stern¹, Gerhard Laub⁴, and Roland G Henry¹

¹Neurology, University of California San Francisco, San Francisco, CA, United States, ²Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Neurology, University Hospital Basel, University of Basel, Basel, Switzerland, ⁴Siemens Healthcare USA, San Francisco, CA, United States, ⁵Neuroscience Imaging Center, University of California San Francisco, San Francisco, CA, United States

The goal of the present work was to test the reliability of the C2-C3 spinal cord gray matter and total cord areas measurements performed using a 2D-PSIR sequence. Nine healthy subjects were scanned twice with repositioning in between the scans (test/retest) on three different 3T scanners with different hardware. On the phase sensitive-reconstructed images, total cord area was measured in a semi-automated way and gray matter area was estimated by using an automatic segmentation method. Evaluations of contrast to noise ratio, intra-scanner and inter-scanner reliability suggest that multicenter studies using a 2D-PSIR sequence are feasible.

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