Abstract #4420

Iron deposition in the globus pallidus of healthy youth

Karthik Prabhakaran¹, David Roalf¹, Mark Elliott¹, Simon Vandekar¹, Kosha Ruparel¹, Ryan Hopson¹, Efstathios D Gennatas¹, Jeffrey Valdez¹, Chad Jackson¹, Theodore Satterthwaite¹, Raquel Gur¹, and Ruben Gur¹

¹University of Pennsylvania, Philadelphia, PA, United States

R2*, the transverse relaxation rate was used to measure iron deposition in the globus pallidus of 815 youth and young adults between the ages of 8 and 22. Significant iron deposition occurs in the globus pallidus between the ages of 8 and 22 in accordance with previously described models of iron deposition in the brain throughout the lifespan. Among adolescents (age 12-16) females had lower iron deposition in the globus pallidus (p < 0.001) as compared to males, this may be related to adolescent females being especially susceptible to dietary iron deficiency because of poor dietary intake in conjunction with high iron requirements related to rapid growth and menstrual blood loss.

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