Miyuki Takasu1, Yuji Akiyama1, Chihiro Tani1, Yoko Kaichi1, Takayuki Tamura1, Koichi Oshio2, and Kazuo Awai1
1Diagnostic Radiology, Hiroshima University Hospital, Hiroshima-shi, Japan, 2Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan
The
purpose of this study was to quantitatively compare various diffusion
parameters obtained from monoexponential, biexponential, and gamma distribution
models in differentiating vertebral lesions
in human subjects. All MR parameters, except for ADCfast
and frac > 3, were significantly different between normal bone marrow and
lesions. Water molecular diffusion parameters may provide additional
information and improve the differentiation of spinal lesions compared with
conventional diffusion parameters. This also refers to differentiation of
malignant lesions from acute spinal fracture, in which both PG (D) calculated
from gamma distribution model and perfusion fraction f of the biexponential
model proved to be useful.
