Abstract #4478

Quantification of vertebral bone marrow fat fraction using time-interleaved multi-echo gradient-echo water-fat MRI: preliminary experience in children

Stefan Ruschke¹, Amber Pokorney², Holger Eggers³, Jan S. Kirschke⁴, Thomas Baum⁵, Dimitrios C. Karampinos¹, and Houchun Harry Hu²

¹Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ²Radiology, Phoenix Children's Hospital, Phoenix, AZ, United States, ³Philips Research, Hamburg, Germany, ⁴Section of Diagnostic and Interventional Neuroradiology, Technische Universität München, Munich, Germany, ⁵Department of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany

In this work, we describe our preliminary clinical experience using a previously reported time-interleaved six-echo gradient-echo (TIMGRE) acquisition for water-fat chemical-shift encoded MRI. The acquisition scheme involved two interleaves that acquired three echoes each with fly-back gradients. The pulse sequence was used to quantify vertebral bone marrow fat fraction in a pilot cohort of 12 pediatric patients (age range: 1-13 years) at 3T with 1.2-1.6 mm in-plane resolution and 1.2-3 mm slices. The knowledge on bone marrow fat fraction may provide insight into adverse effects on bone health later in life, given that there is clinical relevance of vertebral osteoporotic fractures in adults.

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