Functional Changes in Medial Gastrocnemius from Unilateral Limb Suspension Induced Acute Atrophy: a 2D Strain Rate Study during Isometric Contraction
Vadim Malis1, Usha Sinha2, Robert Csapo3, and Shantanu Sinha3
1Physics, University of California at San Diego, San Diego, CA, United States, 2Physics, San Diego State University, San Diego, CA, United States, 3Radiology, University of California at San Diego, San Diego, CA, United States
Unilateral limb suspension is a controlled
method to generate acute atrophy. The
loss of muscle force with acute atrophy may be due to changes in contractile
elements and extracellular matrix (ECM); a study of the strain rate (SR) patterns
could provide information on these changes.
Subjects were assessed at baseline (pre-ULLS) and post-ULLS using
dynamic velocity encoded phase contrast MR imaging. The indices extracted from the SR tensor show
at post-ULLS (i) a decrease in the asymmetry of deformation in the fiber
cross-section and (ii) larger SR-muscle fiber angles. These findings may reflect a loss of
integrity in the ECM.
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