Abstract #4511

Comparison of T2-prepared 3D TSE with multi-echo spin-echo sequences for T2 mapping of thigh muscles in healthy volunteers

Elisabeth Klupp¹, Dominik Weidlich², Thomas Baum², Barbara Cervantes², Marcus Deschauer³, Hendrik Kooijman⁴, Ernst J. Rummeny², Claus Zimmer¹, Jan S. Kirschke¹, and Dimitrios C. Karampinos²

¹Neuroradiology, Technische Universität München, München, Germany, ²Radiology, Technische Universität München, München, Germany, ³Neurology, Technische Universität München, München, Germany, ⁴Philips Healthcare, Hamburg, Germany

There is a growing interest for applying T2 mapping for non-invasively tracking inflammatory changes in patients with neuromuscular diseases. T2 has been traditionally quantified using multi-echo spin-echo (MESE) sequences with known problems related to the refocusing pulses in presence of B1-inhomogeneity and slice profiles effects. The present work proposes the combination of an adiabatic T2-preparation with 3D TSE for B1-insenstive T2 mapping. The proposed method is compared with 2D-MESE and 3D-MESE, in terms of reproducibility on T2 quantification and sensitivity to B1 effects, in the thigh musculature of ten healthy subjects.

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