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Abstract #4513

Quantitative Assessment of Muscle Fat in Sarcopenia Using Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)

Alexandra Grimm1,2, Heiko Meyer2, Mathias Nittka2, Esther Raithel2, Andreas Friedberger1, Marc Teschler1, Michael Uder3, Wolfgang Kemmler1, Klaus Engelke1, and Harald H. Quick1,4

1Institute of Medical Physics, Erlangen, Germany, 2Product Definition & Innovation, Siemens Healthcare GmbH, Erlangen, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany

Sarcopenia describes muscle degeneration. In particular with increasing age, muscle tissue is replaced by fatty infiltrations. We developed an MRI sequence protocol (T1w TSE, PDw SPACE, PDw TSE Dixon, q-Dixon, and HISTO) for quantifying this degradation and applied it twice to 54 patients suffering from sarcopenia. Between both measurements three months of whole body electromyostimulation (EMS) training were performed. Initial results show that image data can be used for muscle segmentation and determination of muscle volumes, fat fractions, and fat distribution within the muscles. Muscle fat fractions correlate with muscle strength. In spectroscopy accurate voxel repositioning is challenging.

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