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Abstract #4521

1H MRS can detect and quantify acetylcarnitine in different human skeletal muscles at rest at 7T.

Radka Tušková1,2,3, Ladislav Valkovič1,3,4,5, Martin Gajdošík1,3, Thomas Heckmann6, Norbert Bachl6, Harald Tschan6, Siegfried Trattnig1,3, and Martin Krššák1,3,7

1High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Faculty of Chemical and Food Technology, Department of NMR Spectroscopy and Mass Spectrometry, Slovak University of Technology in Bratislava, Bratislava, Slovakia, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 5Department of Imaging Methods, Institute of Measurements Science, Slovak Academy of Sciences, Bratislava, Slovakia, 6Center of Sport Science and University Sport, University of Vienna, Vienna, Austria, 7Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Carnitine plays an important role in fat metabolism. A long-echo time (TE of 350ms) proton magnetic resonance spectroscopy protocol was implemented for detection of skeletal muscle acetylcarnitine at rest on a clinical 7T scanner in the calf (soleus) and thigh (vastus lateralis) muscle. T2 relaxation times of the 2.13 ppm signal of acetlylcarnitine at 7T were assessed as 137.8±47.7ms. Concentrations of acetylcarnitine in vastus lateralis muscle in four healthy volunteers were found to be 1.69±0.21mmol/kg wet weight, whereas lower concentrations (i.e., 0.54±0.19mmol/kg) were found in soleus muscle.

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Abstract