Abstract #0030

Multi-Parametric MRI at 7 T Enables Differentiation of MS and Age-Related White Matter Lesions

Zahra Hosseini^1,2, David A. Rudko³, Jacob A. Matusinec⁴, Marcelo kremenchutzky ⁵, Ravi Menon^2,6, and Maria Drangova^1,6,7

¹Biomedical Engineering Graduate Program, University of Western Ontario, London, ON, Canada, ²Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, ³Montreal Neurological Hospital and Institute, McGill University, Montreal, QC, Canada, ⁴Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada, ⁵Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada, ⁶Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, ⁷Imaging Research Laboratories, Robarts Research Institute

MRI enables visualization of white matter lesions associated with demyelination in multiple sclerosis (MS). However, subtle white matter hyperintensities are also a sign of normal aging. This study used information collected from multiple 7T MRI contrasts at baseline and four-month follow-up time points to compare signal changes in lesions of five MS patients to those of age-related lesions (ARLs) in five healthy controls.

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