Abstract #0035

PET/MR Imaging of Metabolic Bone Activity in Osteoarthritis

Feliks Kogan¹, Audrey Fan¹, Emily McWalter², Uchechukwuka Monu¹, Edwin Oei³, Andrew Quon¹, and Garry Gold^1,4,5

¹Radiology, Stanford University, Stanford, CA, United States, ²2Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, ³Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Department of Bioengineering, Stanford University, Stanford, CA, United States, ⁵Department of Orthopaedic Surgery, Stanford University, San Francisco, CA, United States

Osteoarthritis (OA) is a leading cause of disability, resulting in reduced quality of life, at tremendous societal cost. New hybrid PET/MR systems allow for simultaneous, sensitive, and quantitative assessments of early bone activity in OA with PET, which can be correlated with high-resolution quantitative MR methods of soft tissues to study the pathogenesis of OA. We demonstrate promising initial results of simultaneous PET/MR hybrid imaging of knee OA. Results suggest that PET/MR may detect metabolic abnormalities in subchondral bone, which appear normal on MRI. These advancements will allow us to detect and track early and reversible changes in OA.

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