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Abstract #0042

Multiparametric Characterization of Myocardial Tissue by Contrast-Enhanced Cardiac Magnetic Resonance Imaging in Subjects with Prediabetes, Diabetes and Controls from a Western General Population – Results of the KORA-MRI-Study

Corinna Christina Storz1, Holger Hetterich2, Roberto Lorbeer2, Sigrid Auweter2, Wolfgang Rathmann3, Christopher L Schlett4, Annette Peters5,6,7, Konstantin Nikolaou8, Fabian Bamberg8, and Jeanette Schulz-Menger9,10

1Radiology, University Hospital Tuebingen, Tuebingen, Germany, 2Clinical Radiology, Ludwig-Maximilians-University Munich, Germany, 3Biometry and Epidemiology, German Diabetes Center Duesseldorf, Germany, 4Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany, 5Epidemiology II, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany, 6Cardiovascular Prevention, Ludwig-Maximilians University Munich, Munich, Germany, 7German Center for Cardiovascular Disease Research (DZHK e.V.) Munich, Munich, Germany, 8Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany, 9Cardiology, Charité, Experimental and Clinical Research Center and HELIOS-Clinics Berlin-Buc, Germany, 10German Center for Cardiovascular Disease Research (DZHK e. V.) Partnersite Berlin, Germany

Cardiac magnetic resonance imaging (CMR) allows for detailed characterization of the myocardium, which may be beneficial in assessing cardiomyopathy in the setting of hyperglycemic states. We performed a comprehensive CMR protocol in subjects with prediabetes, diabetes and controls and preserved left ventricular (LV) ejection fraction (EF) in a western population-based sample. Subjects with prediabetes and diabetes had an increased LV-remodeling-index as well as higher estimates of cell volume compared with controls, while extracellular volume, as a parameter of diffuse myocardial fibrosis (MF), was decreased. This may highlight the role for hypertrophy in the pathogenesis of diabetic cardiomyopathy in this western population.

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