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Abstract #0046

Non-contrast free breathing and motion corrected 3D whole heart quantitative magnetization transfer imaging for assessment of myocardial fibrosis

Karina Lopez1, Radhouene Neji1,2, Rahul Mukherjee1, John Whitaker1, Reza Razavi1, Camila Muñoz1, Claudia Prieto1, Sebastien Roujol1, and Rene Botnar1

1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom

We have developed a contrast-free free-breathing motion corrected (100% scan efficiency) 3D whole heart imaging technique for measurement of myocardial magnetization transfer ratio (MTR) maps. The sequence is based on the interleaved acquisition of MT weighted and non-MT weighted datasets and beat-to-beat rigid motion correction using 2D image navigators. Initial results in 4 healthy volunteers have shown good image quality, enabling the visualisation of the coronary arteries and MTR maps of healthy myocardium (MTR=41±7.2%). This approach promises higher sensitivity for measuring changes in macromolecule content associated with myocardial fibrosis than previous studies, justifying further investigation in a patient cohort.

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