Abstract #0056

White matter changes and correlations with cognitive functions in semi-acute mild traumatic brain injury (mTBI): A hybrid diffusion imaging study

Sourajit Mitra Mustafi¹, Chandana Kodiweera², Jaroslaw Harezlak³, Laura A Flashman⁴, Thomas W McAllister⁵, and Yu-Chien Wu¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Psychological and Brain Sciences, Dartmouth College, Lebanon, NH, United States, ³Department of Biostatistics, Indiana University, Indianapolis, IN, United States, ⁴Department of Psychiatry, Dartmouth Hitchcock Medical Center and New Hampshire Hospital, Lebanon, NH, United States, ⁵Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

In the present study, we used multi-shell Hybrid Diffusion Imaging (HYDI) to study changes in white matter after mild traumatic brain injury (mTBI). From HYDI data, an array of diffusion metrics was computed including diffusion tensor imaging (DTI), neurite orientation distribution and density (NODDI), and return-to-origin (P₀) of the q-space analysis. We study between group differences in diffusion metrics and within-group correlations with outcomes of cognitive functions. In addition, we tested the group effects (i.e., interaction or moderation) on the correlations between diffusion metrics and cognitive functions.

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