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Abstract #0094

Magnetic Resonance Imaging of the Functional Anatomy of the Oblique Muscles in Patients with Primary Oblique Overaction

Qianwen Gong1,2, Longqian Liu1,3, and Miroslaw Janowski2,4

1Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, People's Republic of China, 2Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, People's Republic of China, 4NeuroRepair Department, Mossakowski Medical Research Centre PAS, Warsaw, Poland

The cause of primary eye movement abnormality is unknown. The functional MRI of superior and inferior oblique muscles was instrumental to investigate the cause of overaction. We have shown similar size of superior oblique muscle in patients and controls in the resting state, while the MRI performed during gazes revealed differences in the contractility, what suggests the abnormal innervation as a cause of primary superior oblique muscles. In contrast, the inferior oblique muscle was larger in resting state, without a difference in contractility what indicates the hypertrophy as a basis for primary inferior oblique muscle overaction.

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