Insulin resistance is a defining feature of type 2 diabetes – a disease associated with severe morbidities and mortality. Recent studies have suggested that adipose tissue hypoxia is a major common pathway to systemic insulin resistance. The goals of this work are to: (i) directly observe evidence of the hypoxia-driven insulin resistance hypothesis in human subjects via gold-standard invasive pO2 measures and (ii) establish an R1-based pO2 metric for future non-invasive studies of adipose pO2 in metabolic disease. Herein, we report initial progress towards these goals.
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