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Abstract #0126

Anatomical and functional deficits of the placenta identified by MRI in a rat model of preeclampsia

Emily Alexandria Waters1, Pamela Monahan2, Chad R Haney1, Michael Kevin Fritsch3, Thomas J Meade4, and Kelly E Mayo2

1Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, United States, 2Molecular Biosciences, Northwestern University, Evanston, IL, United States, 3Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 4Chemistry, Molecular Biosciences, and Neurobiology, Northwestern University, Evanston, IL, United States

Though a large percentage of poor pregnancy outcomes such as stillbirth and preterm birth are related to placental dysfunction, the gold-standard of diagnosing placental pathology remains examination of the placenta by a pathologist after delivery. We demonstrate that anatomical and functional MRI can detect features of placental pathology correlating with ex vivo measures in a rat model of pre-eclampsia.

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