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Abstract #0168

Hyperpolarized 13C Magnetic Resonance Evaluation of Renal Ischemia Reperfusion Injury in a Murine Model

Celine Baligand1, Hecong Qin2, Aisha True-Yasaki2, Jeremy W. Gordon2, Cornelius VonMorze2, Justin DeLos Santos2, Joy P. Walker3, David M. Wilson2, Robert L. Raffai3, John Kurhanewicz2, David H. Lovett4, and Zhen J. Wang2

1Department of Radiology, Leiden University Medical Center, C.J. Gorter Center for High-field MRI, Leiden, Netherlands, 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 3Department of Surgery, University of California San Francisco, San Francisco, CA, United States, 4Department of Medicine, University of California San Francisco, San Francisco, CA, United States

Persistent oxidative stress and mitochondrial dysfunction have been implicated across diverse forms of acute kidney injury and in the transition to chronic kidney disease. We show that HP 13C metabolic MR can be used to noninvasively assess the altered renal redox capacity and mitochondrial PDH activity following ischemic reperfusion injury. Such an imaging approach can potentially enhance the prediction and monitoring of progressive kidney injury.

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