Abstract #0170

Measurement of metabolic changes in acute doxorubicin-induced cardiotoxicity in mice using hyperpolarized [1-13C]pyruvate

David Martin¹, Hikari AI Yoshihara^1,2, Emine Can², Roger Hullin¹, and Jessica AM Bastiaansen³

¹Division of Cardiology, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Institute of Physics, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, ³Department of Radiology, Hospital Lausanne (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Chemotherapy cocktails containing doxorubicin produce irreversible cardiotoxic side effects that may progress to heart failure, which can only be avoided through dose limitation of the chemotherapeutic agents. Increasing evidence suggest that cardiac dysfunction caused by doxorubicin is triggered by an energetic deficit and alterations in mitochondrial metabolism. We quantified metabolic changes in vivo in a mouse model of acute doxorubicin-induced cardiotoxicity using hyperpolarized ¹³C MRS.

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