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Abstract #0183

Brain MR image intensity normalization in the presence of pathology

Hugo J Kuijf1, Mariëlle JA Jansen1, Mirjam I Geerlings2, and Max A Viergever1

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Epidemiology, University Medical Center Utrecht, Utrecht, Netherlands

Brain MR image intensities do not have a fixed tissue-specific value. Especially in longitudinal studies, where a subjects’ anatomy might change, pathology can arise, scanner software and hardware may be replaced, the resulting image intensities can differ widely. This thwarts subsequent post-processing or image analysis. Various image intensity normalization techniques exist, but are often evaluated on healthy subjects. In this work, we evaluate six normalization techniques on 25 image-pairs (five year interval) of subjects with brain pathology. Traditional methods (e.g. Gaussian and Z-Score) are clearly affected by the presence of pathology and perform less than more recent techniques.

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