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Abstract #0190

Altered grey matter volume in patients with type 2 diabetes mellitus

Jia Liu1, Taiyuan Liu2, Wenhui Wang2, Lun Ma2, Xiaoyue Ma2, Shaojie Shi2, and Meiyun Wang2

1Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China, 2Department of Radiology, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China

Our meta-analysis indicates that patients with T2DM have significantly and robustly reduced grey matter, mainly in the cortical-striatal-limbic networks. The meta-regression results suggest that T2DM patients with longer illness duration may have smaller grey matter volume in the right MTG. Our finding supports the notion that T2DM could lead to subtle diabetic brain structural changes, which may be correlated with cognitive impairment inT2DM patients.

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