Abstract #0196

Quantitative Chemical Exchange Saturation Transfer (CEST) Imaging with Magnetic Resonance Fingerprinting (MRF)

Shuning Huang¹, Ouri Cohen^1,2, Michael T. McMahon^3,4, Young R. Kim^1,2, Matthew S. Rosen^1,2,5, and Christian T. Farrar^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³The Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Department of Physics, Harvard University, Cambridge, MA, United States

CEST MRI suffers from several limitations including long image acquisition times and the qualitative nature of the CEST contrast. Clinical translation of CEST MRI would benefit greatly from the development of quantitative and rapid CEST methods. Here we build on the recently developed Magnetic Resonance Fingerprinting (MRF) technique and report the first use of a fast CEST fingerprinting method for generating quantitative exchange rate and exchangeable proton concentration maps of L-Arginine phantoms and a permanent MCAO rat stroke model.

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