Abstract #0213

MS lesions demonstrating a QSM hyperintense-rim have more myelin loss compared to those without a QSM hyperintense-rim

Yihao Yao¹, Thanh D. Nguyen², Sneha Pandya², Sandra Hurtado Rúa³, Amy Kuceyeski⁴, Yi Wang^2,5, and Susan A. Gauthier⁶

¹Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & T, Wuhan, People's Republic of China, ²Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ³Department of Mathematics, Cleveland State University, Cleveland, OH, ⁴Department of Radiology, Weill Cornell Medicine Feil Family Brain and Mind Research Institute, New York, NY, United States, ⁵Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁶Department of Neurology, Weill Cornell Medical College, New York, NY, United States

Iron causes proinflammatory activation of microglia near the rim of white matter MS lesion. This is chronic inflammation with associated myelin tissue damage. We propose to use quantitative susceptibility mapping (QSM) to assess chronic inflammation, as hyperintense rim on QSM can be unequivocally interpreted as iron. We use myelin water fraction (MWF) to measure myelin. We have found that MS lesions with hyperintense rims on QSM have lower MWF and higher susceptibility compared to lesions without hyperintense rims on QSM (p<0.01). Hyperintense rim on QSM may provide a biomarker for tissue injury due to iron associated chronic inflammation.

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