Many clinical scenarios necessitate evaluation for hepatic steatosis or iron overload without indication for a complicated MR exam. Emerging confounder-corrected chemical shift encoded MRI (CSE-MRI) techniques can provide simultaneous estimation of liver proton density fat fraction (PDFF) and R2* as biomarkers of steatosis and iron overload, respectively. We have developed a highly focused CSE-MRI protocol which obtains these metrics in approximately 5 minutes of table time. Our initial clinical experience has shown this protocol to be feasible for evaluation of patients ranging from pediatric to geriatric, with clinically significant disease detected in a large fraction of patients scanned to date.
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