Global signal regression (GSR) is a commonly used preprocessing approach in the analysis of resting state fMRI data. Utilizing simultaneously acquired EEG/fMRI data in humans, we found that GSR alters the correlation between the resting-state BOLD fluctuations and EEG vigilance. We show that GSR reveals BOLD-EEG correlations that are otherwise obscured and use a time segmentation approach to argue that the observed effects are not simply an artifact of GSR.
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