Surgical resection of the mesial temporal lobe is a common treatment of drug-resistant temporal lobe epilepsy (TLE). The ability to more accurately predict post-surgical seizure outcome in these patients is a significant clinical challenge. Towards this end, MRI functional and structural connectivity were used to identify a common pattern across a seizure propagation network in TLE patients with seizure free outcome. Then, in test patients with good and bad outcomes, similarity with the model pattern was significantly associated with seizure outcome. Therefore, this non-invasive method may predict seizure outcomes in TLE, which was not possible from the clinical assessments alone.