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Abstract #0257

Radiogenomics of 201 WHO grade 2 and 3 gliomas

Manabu Kinoshita1,2, Hideyuki Arita2, Masamishi Takahashi3, Yoshitaka Narita3, Yuzo Terakawa2, Naohiro Tsuyuguchi2, Yoshiko Okita2, Masahiro Nonaka2, Shusuke Moriuchi2, Junya Fukai2, Shuichi Izumoto2, Kenichi Ishibashi2, Yoshinori Kodama2, Kanji Mori2, Koichi Ichimura3, and Yonehiro Kanemura2,4

1Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, 2Kansai Molecular Diagnosis Network for CNS Tumors, Osaka, Japan, 3National Cancer Center Hospital, Japan, 4Osaka National Hospital, Osaka, Japan

Genetic alterations found in WHO grade 2 and 3 gliomas include IDH1/2 and TERT promoter mutations and 1p19q co-deletion. In this research, the authors attempted to test the hypothesis that genetic alterations could contribute to the locations and texture of the tumor by analyzing 201 WHO grade 2 and 3 gliomas using radinogenomic analysis. The authors were able to confirm the hypothesis that genetic alterations do contribute to the locations and textures of the tumor. 15 radionomic features were identified and those features were able to identify 3 genetic subgroups of WHO grade 2 and 3 gliomas.

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