Abstract #0270

Highly sensitive pH mapping during ischemia using Total Fast-exchanging Protons (TFP) imaging

Jiadi Xu¹, Kathryn Schunke^1,2, Lin Chen^1,3, Xiang Xu¹, Yuguo Li¹, Guanshu Liu¹, Shuhui Cai³, Raymond C Koehler², Jiangyang Zhang⁴, Peter C. M. van Zijl¹, and Nauder Faraday²

¹kirby Center / Radiology Department, Kennedy Krieger Institute / Johns Hopkins Univeristy, baltimore, MD, United States, ²Department of Anesthesiology/Critical Care Medicines, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, ⁴Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States

Ischemia in a mouse stroke model was assessed by pH mapping using the on-resonance variable-delay multi-pulse (onVDMP) CEST scheme. In the method, an on-resonance binomial pulse train is applied at the water resonance to achieve high labeling efficiency for fast-exchanging protons. Since the CEST signal intensity for the total fast-exchanging protons is far greater than that of amide protons, high detection sensitivity is expected. The final stroke region determined by the method was verified by histologic analysis.

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