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Abstract #0328

Hyperpolarized Micro-NMR for Metabolic Flux Analysis in Cancer Stem Cells and Rapid Assessment of Therapeutic Response

Sangmoo Jeong1, Roozbeh Eskandari1, Sun Mi Park2, Ralph Weissleder3,4, Michael G. Kharas2,5, Hakho Lee3,4, and Kayvan R. Keshari1,5

1Department of Radiology/Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Center for Cell Engineering/Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Center for Systems Biology, Massachusetts General Hospital, Boston, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Weill Cornell Medical College, New York, NY, United States

Aberrant metabolic features of cancer cells are closely related to tumorigenesis and therapeutic response. Here, we report a sensitive magnetic resonance sensing platform, capable of analyzing metabolic fluxes in mass-limited samples. Termed hyperpolarized micromagnetic resonance spectrometer (HMRS), this platform achieved to characterize the metabolic flux in cancer stem cells in real-time and assess therapeutic responses much earlier than any changes in cell viability. This will become a versatile platform for rapid and sensitive exploration of metabolic dynamics in cancer.

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