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Abstract #0355

Measurements of Oxygen Delivery and Consumption  Using Hematocrit Derived from Blood T1 Quantification

Feng Xu1,2,3, Wenbo Li1,2, Peiying Liu1,2, Hanzhang Lu1,2, John J. Strouse4, James J Pekar1,2, Peter C.M. van Zijl1,2, and Qin Qin1,2

1F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiology Science, Johns Hopkins University, Baltimore, MD, United States, 3Developing Brain Research Laboratory, Children's National Medical Center, Washington DC, DC, United States, 4Department of Medicine, Duke University, Durham, NC, United States

We verified that venous blood T1 quantified in vivo in humans using fast and non-invasive MRI can be used to derive hematocrit (Hct) values reliably. This Hct information can be used for a more individual estimation of oxygen extraction fraction (OEF) from venous blood T2 measurements. Furthermore, inverse correlation between Hct and baseline cerebral blood flow (CBF) was observed across subjects. Measurement of Hct, OEF and CBF allowed determination of oxygen delivery (OD~CBF∙Hct) and consumption (cerebral metabolic rate of oxygen, CMRO2~CBF∙Hct∙OEF). When compared to CBF, OD and CMRO2 showed less inter-subject variations among normal volunteers.

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