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Abstract #0367

Determining the T1 of the water in the liver by modelling the effects of fat, iron and off-resonance frequencies on MOLLI T1 measurements

Ferenc Emil Mozes1, Elizabeth Mary Tunnicliffe1, Thomas Marjot2, Christina Kim Levick1,3, Michael Pavlides1,3, and Matthew David Robson1

1University of Oxford Centre for Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, 3Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom

The frequency dependence of balanced steady-state free precession signals causes significant alterations in modified Look-Locker inversion recovery T1 measurements of livers with fat accumulation, leading to either under- or over-estimation of liver T1 values. This is further to the already-known influence of iron. The present study shows a possibility to correct for these effects, yielding a T1 measurement that represents the T1 of the water component independent of the fat and is tested both in phantoms and human participants.

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