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Abstract #0380

The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1ρ

Valentina Mazzoli1,2,3, Danny Tsui2, Larry de Graaf2, Klaas Nicolay2, Andre M Sprengers3, Dennis Janssen3, Nico Verdonschot3, Aart J Nederveen1, and Gustav J Strijkers4

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Orthopaedic Research Lab, Radboud UMC, Nijmegen, Netherlands, 4Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T increases.

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