Abstract #0393

Age-related changes in cerebrovascular reactivity and their relationship to cognition and vascular risk: A four-year longitudinal study

Shin-Lei Peng^1,2, Xi Chen³, Yang Li¹, Karen M Rodrigue³, Denise C Park³, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Imaging and Radiological Science, China Medical University, ³Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas

Although cerebrovascular factors are the cause of cognitive impairment, the vascular decline in aging have not been characterized. In this work, we present four-year longitudinal cerebrovascular reactivity (CVR) data measured in 116 individuals. Our data revealed temporal lobe showed the fastest CVR decline and middle age manifested the fastest CVR decline. Vascular risk of hypertension results in a lower CVR when compared to normal and well-controlled subjects. Individuals with poorer general cognitive status, as indexed by a low mini-mental-state-exam (MMSE), had a lower CVR compared to participants with higher MMSE scores. These findings help elucidate age-related decline in brain hemodynamics.

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