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Abstract #0413

Repeatability and reproducibility of spinal cord atrophy measurements in a multiple sclerosis population using the Spinal Cord Toolbox

Benjamin De Leener1, Tobias Granberg2,3, Katharina Fink4,5, Nikola Stikov1,6, and Julien Cohen-Adad1,7

1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, 3Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, 4Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 5Department of Neurology, Karolinska University Hospital, Stockholm, Sweden, 6Montreal Heart Institute, Montreal, QC, Canada, 7Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada

Spinal cord atrophy is a major determinant of physical disability in multiple sclerosis (MS) and other diseases with neurodegeneration. The upper spinal cord cross-sectional area (CSA) is therefore a clinically important measurement reflecting global spinal cord atrophy. New image analysis software enable semi- and fully-automatic quantification of spinal cord atrophy. This study characterizes the repeatability and reproducibility of semi-automatic CSA measurements of the spinal cord in healthy subjects and in patients with multiple sclerosis, using the Spinal Cord Toolbox (SCT). Results demonstrated the high repeatability and reproducibility of CSA measures using SCT in both healthy persons and in MS.

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