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Abstract #0433

Quantitative Free-Breathing Dynamic Contrast-enhanced MRI in Hepatocellular Carcinoma Using Gd-EOB-DTPA:Correlations With Ki67 Proliferation Status and Histological Grades

Jie Chen1, Chenyang Chen1, Chunchao Xia2, and Bin Song2

1West China Medical School of Sichuan University, Chengdu, People's Republic of China, 2Departmento of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China

This study aims to validate a free-breathing DCE-MRI in HCC patients using gadoxetic acid, and to determine the relationship between DCE-MRI parameters and histological results. Perfusion parameters (Ktrans, Kep, Ve and iAUC) from 34 patients were compared with CT results and correlated with Ki67 indices and the histological grades of HCC. Significant relationship was found between DCE-MRI and CT results, indicating the validity of this protocol in evaluating the vascular change of HCC. The DCE-MRI derived Ktrans and iAUC were significantly correlated with the histological grades of HCC, suggesting the potential of those parameters in predicting the malignancy of tumors.

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